Synonyms for actriia or Related words with actriia

actriib              actrii              tweakr              trii              bmprii              neublastin              norrin              ngr              myostatin              netrin              sclerostin              rspondin              ldcam              flrg              klotho              gdnfr              dmgpcr              metrnl              proneurotrophins              neokine              sost              follistatin              sirp              actria              fzd              ectodomains              pellino              igfbp              pilr              metrn              phosphatonin              taci              nogo              prongf              galectin              plexin              prodomain              neuropilin              tccr              actrib              neuregulin              notum              ephrin              dctsp              prokineticin              hjv              hifn              bcma              neuregulins              persephin             



Examples of "actriia"
The signaling complex for bone morphogenetic proteins (BMP) start with a ligand binding with a high affinty type I receptor (ALK1-7) followed by the recruitment of a type II receptor(ActRIIA, ActRIIB, BMPRII). The first receptor kinase domain is then trans-phosphorylated by the apposed, activating type II receptor kinase domain. GDF2 binds ALK1 and ActRIIB with the highest affinity in the BMPs, it also binds, with a lower affinity ALK2, also known has Activin A receptor, type I (ACVR1), and the other type II receptors BMPRII and ActRIIA. GDF2 and BMP10 are the only ligands from the TGF-β superfamily that can bind to both type I and II receptors with equally high affinity. This non-discriminative formation of the signaling complex open the possibility of a new mechanism. In cell type with low expression level of ActRIIB, GDF2 might still signal due to its affinity to ALK1, then form complex with type II receptors.