Synonyms for cebpb or Related words with cebpb
Examples of "cebpb"
HMGA1 has been shown to interact with
and Sp1 transcription factor.
, HSF2, HSPA1A, HSPA4, Heat shock protein 90kDa alpha (cytosolic) member A1, NCOA6, RALBP1 and SYMPK.
Nucleolar phosphoprotein p130 has been shown to interact with Coilin and
CRSP3 has been shown to interact with Estrogen receptor alpha,
and Cyclin-dependent kinase 8.
CCAAT/enhancer-binding protein beta is a protein that in humans is encoded by the "
Genes coding for transporter proteins that confer multidrug resistance to the cells have also been found to be activated by
. Such genes include ABCC2 and ABCB1.
is capable of increasing the expression of several target genes. Among them, some have specific role in the nervous system such as the preprotachykinin-1 gene, giving rise to substance P and neurokinin A and the choline acetyltransferase responsible for the biosynthesis of the important neurotransmitter acetylcholine.
The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R). It belongs to the tachykinin receptor sub-family of GPCRs. Other neurokinin subtypes and neurokinin receptors that interact with SP have been reported as well. Amino acid residues that are responsible for the binding of SP and its antagonists are present in the extracellular loops and transmembrane regions of NK-1. Binding of SP to NK-1 results in internalization by the clathrin-dependent mechanism to the acidified endosomes where the complex disassociates. Subsequently, SP is degraded and NK-1 is re-expressed on the cell surface. Substance P and the NK1 receptor are widely distributed in the brain and are found in brain regions that are specific to regulating emotion (hypothalamus, amygdala, and the periaqueductal gray). They are found in close association with serotonin (5-HT) and neurons containing norepinephrine that are targeted by the currently used antidepressant drugs. The SP receptor promoter contains regions that are sensitive to cAMP, AP-1, AP-4,
, and epidermal growth factor. Because these regions are related to complexed signal transduction pathways mediated by cytokines, it has been proposed that cytokines and neurotropic factors can induce NK-1. Also, SP can induce the cytokines that are capable of inducing NK-1 transcription factors.
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