Synonyms for cenpf or Related words with cenpf

cenpa              troap              syncrip              rybp              tagln              zwint              aurka              cenpi              anln              ncaph              paics              ldhc              ywhae              ptprk              gmnn              zwilch              ncapg              ccnf              calr              cenpe              ptgds              strbp              aurkb              rbpms              nucks              ptprg              polq              cflar              hmmr              hnrnpc              cebpd              ctsl              sqle              rragd              ptprt              cenpj              ywhab              nktr              cenph              hnrnpr              snrpf              nfkbiz              farsla              ptprd              ugcg              pdxk              dguok              prkaca              hhip              hnrpdl             



Examples of "cenpf"
Centromere protein F is a protein that in humans is encoded by the "CENPF" gene.
The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle. These include CENPE; MCAK; KID; cytoplasmic dynein (e.g., DYNC1H1); CliPs (e.g. CLIP1); and CENPF/mitosin (CENPF). The inner centromere proteins (INCENPs), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis.
Improperly controlled master regulators can reinforce themselves or each other, leading to runaway growth. In aggressive prostate cancer, proteins FOXM1 and CENPF reinforce each other, inadvertently promoting tumor growth. In glioblastoma three proteins collaborate similarly. Similarly two master-regulator proteins govern the malignancy of small-cell lung cancer.
FOXM1 is known to play a key role in cell cycle progression where endogenous FOXM1 expression peaks at S and G2/M phases. FOXM1-null mouse embryos were neonatal lethal as a result of the development of polyploid cardiomyocytes and hepatocytes, highlighting the role of FOXM1 in mitotic division. More recently a study using transgenic/knockout mouse embryonic fibroblasts and human osteosarcoma cells (U2OS) has shown that FOXM1 regulates expression of a large array of G2/M-specific genes, such as Plk1, cyclin B2, Nek2 and CENPF, and plays an important role in maintenance of chromosomal segregation and genomic stability.