Synonyms for dysautonomic or Related words with dysautonomic
Examples of "dysautonomic"
Stepanek suffered from a rare disorder,
mitochondrial myopathy. His three older siblings died from
mitochondrial myopathy, too. The condition was unknown until his mother was diagnosed with mitochondrial disease in 1992, after all four of the children had been born.
This is a form of dysautonomia but differentiated from familial dysautonomia by a lack of familial
symptoms such as loss of sense of pain and smell. While L-threo-DOPS has been described as being "very effective for restoring noradrenergic tone and correcting postural hypotension, response to treatment is variable and the long-term and functional outcome is unknown."
If there is no hypoglycemia at the time of the symptoms, this condition is called "postprandial syndrome." It might be an "adrenergic postprandial syndrome" — blood glucose levels are normal, but the symptoms are caused through autonomic adrenergic counterregulation. Often, this syndrome is associated with emotional distress and anxious behaviour of the patient. This is often seen in
disorders as well. Dietary recommendations for reactive hypoglycemia can help to relieve symptoms of postprandial syndrome.
In 2001, Winfrey met 11-year-old Mattie Stepanek, who was born with
mitochondrial myopathy and wrote inspirational poetry he titled "Heartsongs." On the show, Stepanek stated, "A heartsong doesn't have to be a song in your heart. It doesn't have to be talking about love and peace. … It's your message, what you feel like you need to do." In October 2008, Winfrey spoke at the posthumous dedication of Mattie J.T Stepanek Park in Maryland.
OHS is a milder allelic variant of Menkes disease, having a later age of onset and being associated with far less severe central neurodegeneration. The milder nature of OHS is often attributable to ‘leaky’ splice junction mutations that allow 20–30% of ATP7A messenger RNA (mRNA) transcripts to be correctly processed. As in cases of Menkes disease, individuals with OHS manifest connective tissue abnormalities resulting from deficient activity of lysyl oxidase, a copper-requiring enzyme that normally deaminates lysine and hydroxylysine in the first step of collagen crosslink formation. Such individuals also often endure inconvenient
signs and symptoms related to a partial deficiency in dopamine-β-hydroxylase (DBH) activity. DBH, another copper-dependent enzyme, normally converts dopamine to norepinephrine, a crucial neurotransmitter in norepinephrinergic neurons. A natural mouse model of OHS, the so-called mottled blotchy model, recapitulates the connective tissue abnormalities, DBH deficiency and mild CNS damage seen in humans.
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