Synonyms for eudysmic or Related words with eudysmic
Examples of "eudysmic"
ratio for ethylphenidate is superior to that of methylphenidate.
In pharmacology it is frequently, though not always, the case that one enantiomer of a chiral drug has greater pharmacological activity than the other. The
ratio is a mathematical equation that quantitatively measures the difference in this activity. A
ratio significantly differing from 1 means that there is a difference in activity between the two enantiomers.
As can be seen in the above table, a high
ratio exists for PRC050 with activity residing in the SS enantiomer (PRC200).
ratio (also spelled eudismic ratio) is a term commonly found in the fields of pharmacology, chemistry, and molecular biology which describes the difference in pharmacologic activity between the two enantiomers of a drug.
ratio between the two enantiomers of N-methyl-indatraline is not as high as was reported in the case of tametraline. The toxicity of the R,S isomer is less than for the S,R isomer.
One way the
ratio is computed is by dividing the EC or the IC of the eutomer by the same measurement of the distomer. Whether one chooses to use the EC or IC depends on the drug in question.
Although four stereoisomers of methylphenidate (MPH) are possible, only the threo diastereoisomers are used in modern practice. There is a high
ratio between the SS and RR enantiomers of MPH. Dexmethylphenidate (d-threo-methylphenidate) is a preparation of the RR enantiomer of methylphenidate. In theory, "D"-TMP (d-threo-methylphenidate) can be anticipated to be twice the strength of the racemic product.
It is often the case that only a single one of the enantiomers contains all of the wanted bioactivity, the distomer is often less active, has no desired activity or may even be toxic. In some cases the
ratio is so high that it is desired to separate out the two enantiomers instead of leaving it as a racemic product. It is also possible that the distomer is not simply completely inactive but actually antagonizes the effects of the eutomer. Alternatively, it is possible that the distomer converts in the body into the eutomer, at least partly.
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