Synonyms for gzmb or Related words with gzmb

gzma              gzmk              gzmh              ptprc              procr              plaur              nfkbiz              gzmm              cflar              inhba              gnly              tpbg              nfkbie              ctsz              postn              cebpd              flnb              igj              faslg              nfkbia              lpxn              hbegf              cebpb              vcan              tiparp              ptgds              cpvl              myadm              oplah              cebpe              srgn              emcn              eomes              tdrkh              ctsh              cryab              gypc              dgkb              areg              farsla              itgal              lgmn              nfkbib              rybp              ptprk              rabif              nfic              ptprg              hemgn              aicda             

Examples of "gzmb"
Granzyme B is a serine protease that in humans is encoded by the "GZMB" gene. Granzyme B is expressed by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells.
Other recent research identified Granzyme B (GZMB) (a protein-degrading enzyme) to be a potential target in the treatment of abdominal aortic aneurysms. Elimination of this enzyme in mice models both slowed the progression of aneurysms and improved survival.
Just north of the city a new scientific center has been built in which most of the natural sciences (Chemistry, Biology, Plant Pathology, Agronomy, Forestry, Geology, Physics, Computer Science) are now located, including the GZMB. Other institutes are set around the inner city.
In humans, granzyme B is encoded by GZMB on chromosome 14q.11.2, which is 3.2kb long and consists of 5 exons. It is one of the most abundant granzymes of which there are 5 in humans and 10 in mice. Granzyme B is thought to have evolved from a granzyme H related precursor and is more effective at lower concentrations than the other granzymes.
Early work at CIML was centered on T cells. The study of their antigen receptors lead to the discovery of chromosomal inversion during the formation of the T cell receptor (TCR). Researchers at the CIML also published the first nucleotide sequence of a gene encoding a human major histocompatibility complex (MHC) gene and described how the TCR recognizes its MHC ligand. The functions of these T cells were also investigated, leading in particular to the identification of Granzyme A and GZMB (then called CTLA-1 and CTLA-3) and the demonstration of their playing a role in the perforin-granzyme-based mechanism of T-cell-mediated cytotoxicity, and to the discovery of the second, Fas ligand/Fas receptor based pathway of cytotoxicity. Other biologically important regulatory molecules identified at the CIML include interleukins such as interleukin-17 (as CTLA-8) and cell surface molecules, such as CTLA-4 regulating T cells. Subsequently, research at the CIML expanded to other cells of the immune system, including B cells, dendritic cells and natural killer cells, as well as other models systems, such as "C. elegans". CIML researchers identified the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing KARAP/DAP12 that is important for NK cell function and characterized the key function of the killer activated receptor NKp46. Other recent advances include the discovery of early precursors of B-cell follicular lymphoma in apparently healthy individuals, and of dendritic cell aggresome-like induced structures (DALIS) in dendritic cells, thought to play an important role in regulating antigen presentation, as well as the discovery of MafB/M-CSF circuits in hematopoietic stem cell commitment, and macrophages.