SynonymsBot
Synonyms for hepatocytes or Related words with hepatocytes
adipocytes
fibroblasts
hepatocyte
keratinocytes
cardiomyocytes
astrocytes
islets
mscs
macrophages
myoblasts
chondrocytes
melanocytes
hscs
preadipocytes
monocytes
osteoblasts
nscs
ascs
hescs
myocytes
hepatoblasts
lymphocytes
progenitors
cells
hpstcs
mitochondria
microglia
cardiomyocyte
hmscs
liver
oocytes
oligodendrocytes
myotubes
livers
erythrocytes
organoids
escs
exosomes
thymocytes
hsc
leukocytes
ipscs
adipocyte
pbmcs
neutrophils
astrocyte
hepatic
neurons
embryos
cholangiocytes
Examples of "hepatocytes"
After maturation, the merozoites are released from the
hepatocytes
and enter the erythrocytic portion of their life-cycle. Note that these cells do not reinfect
hepatocytes
.
Primary
hepatocytes
are commonly used in cell biological and biopharmaceutical research. In vitro model systems based on
hepatocytes
have been of great help to better understand the role of
hepatocytes
in (patho)physiological processes of the liver. In addition, pharmaceutical industry has heavily relied on the use of
hepatocytes
in suspension or culture to explore mechanisms of drug metabolism and even predict in vivo drug metabolism.
Hepatocytes
manufacture their own structural proteins and intracellular enzymes.
ES-derived
hepatocytes
are also useful models that could be used in the preclinical stages of drug discovery. However, the development of
hepatocytes
from ES has proven to be challenging and this hinders the ability to test drug metabolism. Therefore, current research is focusing on establishing fully functional ES-derived
hepatocytes
with stable phase I and II enzyme activity.
Advancements in bioengineering techniques in the decade after Matsumara's work have led to improved membrane constructs and hepatocyte attachment systems. As time has progressed the sources of
hepatocytes
have increased. Cell sources now include primary porcine
hepatocytes
, primary human
hepatocytes
, human hepatoblastoma (C3A), immortalized human cell lines and stem cells.
In normal individuals, uptake of Tc mebrofenin by
hepatocytes
is 100%. Decreased liver uptake is indicative of hepatocyte disease. Once in the
hepatocytes
, Tc mebrofenin is "secreted" into the canaliculi and finally "excreted" by the bile ducts.
Hepatocytes
are polyhedral in shape, therefore having no set shape or design. They have surfaces facing the sinusoids, (called sinusoidal faces) and surfaces which contact other
hepatocytes
, (called lateral faces). Bile canaliculi are formed by grooves on some of the lateral faces of these
hepatocytes
.
The histologic diagnosis of hepatic adenomas can be aided by reticulin staining. In hepatic adenomas, the reticulin scaffold is preserved and
hepatocytes
do not form layers of four or more
hepatocytes
, as is seen in hepatocellular carcinoma.
Hepatic adenomas are, typically, well-circumscribed nodules that consist of sheets of
hepatocytes
with a bubbly vacuolated cytoplasm. The
hepatocytes
are on a regular reticulin scaffold and less or equal to three cell thick.
In the smaller portal triads, the four vessels lie in a network of connective tissue and are surrounded on all sides by
hepatocytes
. The ring of
hepatocytes
abutting the connective tissue of the triad is called the periportal limiting plate.
It also appears to play a role in liver invasion by "Plasmodium" species. CD81 is required for "Plasmodium vivax" sporozoite entry into human
hepatocytes
and for "Plasmodium yoelii" sporozoite entry into murine
hepatocytes
.
Glucagon stimulation of PKA also inactivates the glycolytic enzyme pyruvate kinase in
hepatocytes
.
iCell
Hepatocytes
are used in a variety of ways, including prediction of hepatotoxicity in drug development applications. Adverse and unexpected hepatic side effects are one of the most common reasons for drugs to be removed from the market after launch or in late phase clinical trials{iCell
Hepatocytes
are used as a tool for better predicting hepatic toxicity earlier in the drug discovery process. Other companies that provide
hepatocytes
include Cellectis and Life Technologies.
The drug myrcludex B, which inhibits virus entry into
hepatocytes
, is in clinical trials .
Phloretin has been found to inhibit GLUT2 and aquaporin 9 (AQP9) on mouse
hepatocytes
.
Hepatocytes
also synthesize apoproteins with which they then assemble and export lipoproteins (VLDL, HDL).
One of the detoxifying functions of
hepatocytes
is to modify ammonia into urea for excretion.
They also occur physiologically in
hepatocytes
, chondrocytes and in fungi (dikaryon).
In its role as myonectin, it also promotes lipid uptake into adipocytes and
hepatocytes
.
A liver biopsy will show abundant PAS-positive globules within periportal
hepatocytes
.