Synonyms for hhip or Related words with hhip
Examples of "hhip"
The function of
is not well known but has been shown to be tightly associated with lung function. Knocking out
in mice is neonatally lethal due to defective branching in the lung. The heterozygous knockout of
has been shown to contribute to more severe emphysema induced by cigarette smoke compared to wild type mice. Furthermore, increased spontaneous emphysema and oxidative stress levels have been found in the lungs of
heterozygous mice. Both the expression level and enhancer activity of
is reduced in chronic obstructive pulmonary disease (COPD) lungs, suggesting a protective role of
in COPD pathogenesis.
This protein belongs to the
family and is one of three members found in humans. HHIPL1 contains a SRCR domain and an N-terminal signal peptide. Processing of the signal peptide leads to this protein's secretion. As an
member, it also contains a conserved
-homologous (HIPH) domain composed of 18 cysteine residues.
The function of HHIPL1 is not known. The section below refers to the function of
Hedgehog interacting protein is a protein that in humans is encoded by the "
DNA methylation is one of several epigenetic modifications recognized as hallmarks of tumorigenesis. In a genome-wide survey of subtype-specific epigenomic changes in adenoma, the HHIPL1 gene was hypermethylated in 12 of 13 non-functioning (NF) adenomas, as well as in growth hormone (GH)- and prolectin-secreting adenomas. Thus, HHIPL1 has the potential to serve as a biomarker to predict or characterise tumorous growth patterns. Unlike another member of the human
, which is regarded as a pharmacogenomics target in the fields of oncology and vascular medicine, HHIPL1 has yet been reported with such potential.
SHH also induces other proteins with which it interacts, and these interactions can influence the sensitivity of a cell towards SHH. Hedgehog-interacting protein (
) is induced by SHH which in turn attenuates its signaling activity. Vitronectin is another protein that is induced by SHH; it acts as an obligate co-factor for SHH signaling in the neural tube.
-like protein 1 (HHIPL1), also known as HHIP2, is a protein that in humans is encoded by the "HHIPL1" gene on chromosome 14. It is not significantly expressed in many tissues and cell types, though HHIPL1 mRNA has been detected in trabecular bone cells. Little is known about the precise biological function of HHIPL1, but the protein has been linked to adenomas. The "HHIPL1" gene also contains one of 27 SNPs associated with increased risk of coronary artery disease.
Kelly was elected to the Michigan State Senate in 1978 from Detroit and served four consecutive four-year terms. At his first caucus Kelly was elected as majority
and authored over 100 pieces of legislation and amendments that became law, including the state investment anti-apartheid laws for South Africa and the McBride anti-discrimination employment laws for Northern Ireland. He served on committees with jurisdiction over the judiciary, banking and economic development, health policy, local government and public finance. He served on the National Commission on Uniform Law, the Michigan Law Revision Commission and as a delegate to the National Conference on State Legislatures. Kelly served on a National Commission on Distressed States and is committed to projects to revitalize the City of Detroit. In 1994 he stood for election to the U.S. Senate requiring retirement from the state legislature.
The indoor percussion unit (
) under the direction of Antonio Perez and Anthony Kash won the Tournament Indoor SE PA regional championships in 2009, 2010, 2013, and 2014. They won the TIA Atlantic-Coast Championships in 2009, 2010, 2012, 2013, and 2014. In addition, they won the Cavalcade Indoor Association Championships in 2010 and 2013. In Winter Guard International, the unit has competed in the NE US Regionals since 2010 and have been finalists every year. The group finished 2nd place in 2013 and 2014. In 2014 the unit was promoted to the Scholastic Open Class. This year's units will compete in the Mid-Atlantic Percussion Society and Winter Guard International World Championships in Dayton, Ohio.
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