Synonyms for hpse or Related words with hpse

cflar              postn              procr              ptprk              cxadr              gzmb              vcan              ctsl              ctsk              nfkbiz              gzmk              aicda              plaur              spdef              alcam              emcn              pycard              nfkbia              stratifin              eplin              ptgds              rybp              nktr              opcml              anpep              tagln              ptprs              synpo              ptprc              papln              grina              ptprj              ptprn              hnrnpr              inhba              areg              pxdn              tiparp              gzma              cpvl              parvb              hnrnpc              tegt              eomes              agrn              junb              sdcbp              lifr              ptprm              vegfb             



Examples of "hpse"
Heparanase (, "Hpa1 heparanase", "Hpa1", "heparanase 1", "heparanase-1", "C1A heparanase", "HPSE") is an enzyme with systematic name "heparan sulfate N-sulfo-D-glucosamine endoglucanase". This enzyme catalyses the following chemical reaction
Heparanase, also known as HPSE, is an enzyme that acts both at the cell-surface and within the extracellular matrix to degrade polymeric heparan sulfate molecules into shorter chain length oligosaccharides.
Lacritin cell targeting is dependent on the cell surface heparan sulfate proteoglycan syndecan-1 (SDC1). Binding utilizes an enzyme-regulated 'off-on' switch in which active epithelial heparanase (HPSE) cleaves off heparan sulfate to expose a binding site in the N-terminal region of syndecan-1's core protein. A G-protein-coupled receptor (GPCR) then appears to be ligated. Targeted cells signal to NFAT and mTOR if conditions are suitable for proliferation, or to AKT and FOXO3 under conditions of stress.
An exception is the prosecretory mitogen lacritin that binds syndecan-1 only after heparanase modification. Binding utilizes an enzyme-regulated 'off-on' switch in which active epithelial heparanase (HPSE) cleaves off heparan sulfate to expose a binding site in the N-terminal region of syndecan-1's core protein. Three SDC1 elements are required. (1) The heparanase-exposed hydrophobic sequence GAGAL that promotes the alpha helicity of lacritin's C-terminal amphipathic alpha helix form and likely binds to the hydrophobic face. (2) Heparanase-cleaved heparan sulfate that is 3-O sulfated. This likely interacts with the cationic face of lacritin's C-terminal amphipathic alpha helix. (3) An N-terminal chondroitin sulfate chain that also likely binds to the cationic face. Point mutagenesis of lacritin has narrowed the ligation site.