Synonyms for hyperandrogenemia or Related words with hyperandrogenemia
Examples of "hyperandrogenemia"
Not all women with PCOS have difficulty becoming pregnant. For those that do, anovulation or infrequent ovulation is a common cause. Other factors include changed levels of gonadotropins,
and hyperinsulinemia. Like women without PCOS, women with PCOS that are ovulating may be infertile due to other causes, such as tubal blockages due to a history of sexually transmitted diseases.
His research has helped link PCOS with a body's resistance to the effects of insulin by examining the role of miRNA-93, shown how obesity relates to a person's risk of PCOS, and highlighted the adrenal gland's impact on increased androgen in PCOS. In addition, Azziz's work with hyperplasia,
, and other disorders has been published in various journals such as the Journal of Clinical Endocrinology and Metabolism and Journal of Reproductive Medicine.
Endocrine disruption may also directly decrease fertility, such as changed levels of gonadotropin-releasing hormone, gonadotropins (especially an increase in luteinizing hormone),
, and hyperinsulinemia. Gonadotropins are released by gonadotroph cells in pituary gland, and these cells appear to harbor insulin receptors, which are affected by elevated insulin levels. A reason that insulin sensitizers work in increasing fertility is that they lower total insulin levels in body as metabolic tissues regain sensitivity to the hormone. This reduces the overstimulation of gonadotroph cells in pituitary.
Polycystic ovary syndrome (PCOS) is an endocrine disorder characterized by an excess of androgens produced by the ovaries. It is estimated that approximately 90 percent of women with PCOS demonstrate hypersecretion of these hormones. A concrete cause for this condition is currently unknown. Speculations include genetic predisposition, although the gene or genes in particular have yet to be identified. Evidence suggests that the condition may have a hereditary basis. Other possible causes include the effects from an increase in insulin production. Insulin itself has been observed capable of inducing excess testosterone levels in the ovaries. Elevated insulin concentration in the body leads to lower production of sex hormone binding globulin (SHBG), a regulatory glycoprotein that suppresses the function of androgens. High blood levels of insulin also work in conjunction with ovarian sensitivity to insulin to cause
, the primary symptom of PCOS. Obese individuals may be more biologically inclined to display PCOS due to markedly higher amounts of insulin in their bodies. This hormonal imbalance can lead to chronic anovulation, in which the ovaries experiences difficulty releasing mature eggs. These cases of ovulatory dysfunction are linked to infertility and to menstrual disturbances.
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