Synonyms for plexin or Related words with plexin
Examples of "plexin"
B1 is a protein of the
family that in humans is encoded by the "PLXNB1" gene.
Within neural tissues, the
family serves as transmembrane receptors for Semaphorins. Outside of neural tissues,
B1 is implicated in the control of cell migration.
is a protein which acts as a receptor for semaphorin.
acts as a signal transduction molecule in the neuropilin-
receptor complex. Plexins also act as transduction factors for ITAM-DAP12-RANKL signalling pathway involved in osteoclastic differentiation.
A4 binds to neuropilin 1 (Nrp1) and neuropilin 2 (Nrp2) and transduces signals from Sema3A, Sema6A, and Sema6B. These Nrp-
and semaphorin complexes initiate cascades that regulate diverse processes such as axon pruning and repulsion, dendritic attraction and branching, regulation of cell migration, vascular remodeling, and growth cone collapse. Both upregulation and downregulation of
A4 has been observed following neural injury suggesting a dynamic role for Sema3A and
A4 in neural maintenance and regeneration. Additionally, Sema3A and therefore its receptor,
A4, have been implicated as possible components of fast-fatigable muscle fiber denervation in ALS.
-A4 is a protein that in humans is encoded by the "PLXNA4" gene.
-B2 is a protein that in humans is encoded by the "PLXNB2" gene.
This gene encodes a member of the
-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by
-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This
-A family member is thought to transduce signals from semaphorin-3A and -3C.
-B3 is a protein that in humans is encoded by the "PLXNB3" gene.
-A3 is a protein that in humans is encoded by the "PLXNA3" gene.
-A2 is a protein that in humans is coded by the "PLXNA2" gene.
In the adult rat central nervous system (CNS),
A4 was present in neurons and fibers throughout the brain and spinal cord, including neocortex, hippocampus, lateral hypothalamus, red nucleus, facial nucleus, and the mesencephalic trigeminal nucleus. Fibers expressed
A4 in the lateral septum, nucleus accumbens, several thalamic nuclei, substantia nigra pars reticulata, zona incerta, pontine reticular formation, as well as in several cranial nerve nuclei.
A4 has been found in dorsal and, to a greater extent, ventral horns of the spinal cord. Both motor neurons and interneurons in the ventral horn express
A4. Motor axons exiting via the ventral roots and the ascending and descending white matter tracts express
A4. In dorsal root ganglia,
A4 is expressed in the neuronal cell bodies as well as the central and peripheral processes of those cells.
-D1 is a protein that in humans is encoded by the "PLXND1" gene.
-A1 is a protein that in humans is encoded by the "PLXNA1" gene.
domain-containing protein 2 is a protein that in humans is encoded by the "PLXDC2" gene.
domain-containing protein 1 is a protein that in humans is encoded by the "PLXDC1" gene.
In Sema3A signaling cascade, CRMP plays a role as intracellular messenger mediating repulsive signal. Sema3A initiates clustering of the receptor Neuropilin 1 and
A1. While some of the other class of Semaphorins directly bind to
receptors, Sema3A does not bind to
directly. Instead, it interacts with Neuropilins as ligand-binding co-receptor for
-based signaling. The signal transduction pathway downstream of activated
receptor is mediated by CRMPs. In response to Sema3A signaling cascade, CRMPs which exist as a heterotetramer in the cytosol bind to the cytosolic domain of PlexA and its conformation changes. Further, CRMPs are phosphorylated by Cdk5, GSK3β, and Fes, a tyrosine protein kinase. Especially, phosphorylation of CRMP-1 and CRMP-2 are essential for Sema3A-regulated axonal guidance. In the presence of CRMP-2, the signal can induce alterations of Rac-dependent pathway, which modulates the actin filament assembly in the growth cone. In the absence of Sema3A, the interaction between CRMP tetramer and PlexA is blocked. Phospholipase D2 (PLD-2) which is localized in the growth cone and is involved in actin cytoskeleton rearrangement, can be inhibited by CRMP-2 and its inhibition results in actin depolymerization and possibly affects axonal growth cone collapse. In the presence of CRMP-2, the signal can induce alterations of Rac-dependent pathway, which modulates the actin filament assembly in the growth cone.
During skin damage repairs, SEMA4D interacts with
B2 on gamma delta t cells to play a role in the healing process.
A4 has ~1890 amino acids that include a likely signal sequence, transmembrane domain, and 12 extracellular N-linked glycosylation sites. It also contains domains consistent with other class A plexins including a Sema domain, three "Met-related sequences"/cysteine clusters, three extracellular glycine-proline repeats, intracellular SP domains, and a putative intracellular tyrosine kinase phosphorylation site.
The Sema domain is a structural domain of semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor (Uniprot: ),
-A3 (Uniprot: ) and in viral proteins.
Semaphorin 4D (Sema 4D) is an axon guidance molecule which is secreted by oligodendrocytes and induces growth cone collapse in the central nervous system. By binding
B1 receptor it functions as an R-Ras GTPase-activating protein (GAP) and repels axon growth cones in both the mature central nervous system.
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