Synonyms for ptgds or Related words with ptgds
Examples of "ptgds"
Prostaglandin-H2 D-isomerase (
) is an enzyme that in humans is encoded by the "
OPCs synthesize the neuromodulatory factors prostaglandin D2 synthase (
) and neuronal pentraxin 2 (Nptx2). This is mediated by the protein NG2, whose intracellular domain can be cleaved by the γ-secretase and translocated to the nucleus.
Prostaglandin D synthase is used clinically as a diagnostic marker for liquorrhea, that is, to check whether fluid leaking from the nose or ear contains cerebrospinal fluid. This is important in the assessment of head trauma severity. In a medical context, the older term "β-trace protein" is frequently used to refer to
In cells, COX-1 and COX-2 metabolize arachidonic acid to PGH2 which is then converted to PGE2 by any one of three isozymes, PTGES, PTGES2, and PTGES3 or, alternatively, to PGD2 by either of two enzymes, a glutathione-independent synthase termed lipocalin-type Prostaglandin D2 synthase (
or L-PGDS) and a glutathione-dependent hematopoietic-type H-PGDS or PTGDS2; the COX's also metabolizes dihomo-gamma-linolenic acid to PGH1 which is metabolized by one of the three PTGES isomzymes to PGE1 (see eicosanoid#Prostanoid pathways). PGE2, PGE1, and PGD2 undergo a dehydration reaction PGA2, PGA1, and PGJ2, respectively. PGD2 conversions form the most studied cyclopentenone PGs. These conversions are as follows:
The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH) to prostaglandin D2 (PGD). PGD functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice over-expressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. Furthermore,
and its product PGD are elevated in the bald-scalp areas of men with male pattern baldness (androgenetic alopecia).
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