Synonyms for raventoxin or Related words with raventoxin

hwtx              hntx              shtx              aetx              graxos              chiltar              parakkamabahu              saifuddien              colsac              pxphilip              pragmulji              todopoderosos              tantive              teriimaevarua              miesko              hassik              warchalowski              dorekk              gaehyukhapdong              attambelos              eupolypods              tarnax              threemendous              buvanekabahu              cvtx              killerdome              amatokos              wizlaw              wulgrin              megawars              horesco              ihunwo              tagjai              bisterberg              jztx              reviction              viiigeorge              prosolanapyrone              vielizabeth              ramsses              sparoair              sauromates              nonghanji              theonesios              vedward              wiradadaha              hispanicarum              cagsiay              nadiope              aufbaues             



Examples of "raventoxin"
Raventoxin-II and raventoxin-V also have insecticidal effects.
Raventoxin-I and raventoxin-III are not toxic for cockroaches., but administration of Magi-5 (raventoxin-III) in lepidopteran larvae results in temporary paralysis of the insects.
Raventoxin-I and raventoxin-III have both shown excitation, spastic paralysis, gasping, a fast heartbeat and exophthalmos in mice. Only raventoxin-I also shows an increase in salivation. Both toxins can cause death in mice, when sufficiently administered. The LD50 of raventoxin-I is 0.772 mg/kg when intra-abdominally injected in mice.
Raventoxin-V has a molecular weight of 3133.48 Da.
Raventoxin-II has a molecular weight of 3021.56 Da.
Six different types of raventoxin have been described, named raventoxin-I to VI. Raventoxin-I consists of 43 amino acid residues. It has a molecular mass of 4840.11 Da. The toxin is partially homologous to δ-AcTx-Hv1a and δ-AcTx-Ar1, two toxins derived from "Hadronyche versuta" and " Atrax robustus", respectively.
Raventoxin-VI consists of 51 amino acid residues, and has a molecular weight of 5371.6 Da.
Raventoxin-III is a basic polypeptide, consisting of 29 amino acid residues. It has a molecular mass of 3286.58 Da.
Raventoxin-VI blocks neuromuscular transmission in a rat phrenic nerve preparation. Intracerebroventricular injection of the toxin leads to paralysis in rat.
All described raventoxins have shown to exert a neurotoxic effect. At low concentration, raventoxin-I enhances muscle contraction, suggesting a direct action of the toxin on muscle, whereas at higher concentration it blocks neuromuscular transmission. No toxins have shown to act similarly.
The primary structure of raventoxin-III is identical to that of Magi 5 (β-hexatoxin-Mg1a), a toxin found in the venom of the spider "Macrothele gigas". Magi 5 binds at site 4 of the alpha subunit of the mammalian voltage-gated sodium channel Nav1.2 (SCN2A). Binding of Magi 5 to the sodium channels shifts both activation and inactivation to more hyperpolarized voltages and slows the recovery from inactivation. Combined, these effects may lead to increased inactivation of the sodium channels at rest, leading to inhibition and blockage of neuromuscular transmission. The blockage is most probably reversible. Magi-5 competes with the scorpion beta-toxin Css IV for binding to the sodium channelat neurotoxin receptor site 4. One other known property of Magi-5 is its binding to site 3 of the insect sodium channel, observed in lepidopteran larvae, which raises the possibility of homology between the molecular structures of the binding site 3 (in insects) and 4 (in mammals).