Synonyms for sprouty or Related words with sprouty

pikfyve              porcn              fascin              hmga              iqgap              ptpsigma              plexin              cypin              sphk              phlpp              rhogtpase              bbap              ppard              naip              pkciota              rptp              piasy              latexin              oxtr              hdmx              dyrk              kremen              mdmx              dickkopf              galnt              stathmin              caterpiller              netrin              rnpep              schwannomin              plunc              mekk              ttbk              neuropilin              tnik              chibby              cortactin              epha              synaptojanin              ctbp              ancca              foxo              aurkb              chimerin              necdin              etrb              dynactin              pcdgf              gilz              futrin             



Examples of "sprouty"
Protein sprouty homolog 4 is a protein that in humans is encoded by the "SPRY4" gene.
In molecular biology, the protein Sprouty is a developmental protein involved in cell signalling.
Protein sprouty homolog 3 is a protein that in humans is encoded by the "SPRY3" gene.
Protein sprouty homolog 1 is a protein that in humans is encoded by the "SPRY1" gene.
Sprouty-related, EVH1 domain-containing protein 2 is a protein that in humans is encoded by the "SPRED2" gene.
Sprouty homolog 2 (Drosophila), also known as SPRY2, is a protein which in humans is encoded by the "SPRY2" gene.
SPRED2 is a member of the Sprouty (see SPRY1)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1).
Sprouty-related, EVH1 domain-containing protein 3 also known as Spread-3 is a protein that in humans is encoded by the "SPRED3" gene.
Spread-3 is a member of the Sprouty (see SPRY1/SPRED) family of proteins that regulate growth factor-induced activation of the MAP kinase cascade.
Sprouty-related, EVH1 domain-containing protein 1 (Spread-1) is a protein that in humans is encoded by the "SPRED1" gene located on chromosome 15q13.2 and has seven coding exons.
In molecular biology the SPR domain is a protein domain found in the Sprouty (Spry) and Spread (Sprouty related EVH1 domain) proteins. These have been identified as inhibitors of the Ras/mitogen-activated protein kinase (MAPK) cascade, a pathway crucial for developmental processes initiated by activation of various receptor tyrosine kinases. These proteins share a conserved, C-terminal cysteine-rich region, the SPR domain. This domain has been defined as a novel cytosol to membrane translocation domain. It has been found to be a PtdIns(4,5)P2-binding domain that targets the proteins to a cellular localization that maximizes their inhibitory potential. It also mediates homodimer formation of these proteins.
Spread-1 is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade.
SPRY2 is a negative feedback regulator of multiple receptor tyrosine kinases (RTK's) including receptors for fibroblast growth factor (FGF), epidermal growth factor (EGF), and hepatocyte growth factor (HGF). Antagonization of growth factor mediated pathways, cell migration, and cellular differentiation occurs through the ERK pathway. Spry2 can also enhance EGFR signaling by sequestering CBL. Spry gene expression has been reported silenced or repressed in cancer of the breast, liver, lung, prostate, and in lymphoma. Human spry2 expression is localized to the microtubules in unstimulated cells. All sprouty isoforms inhibit the ERK pathway by themselves, but can also form heterodimers and homodimers which have enhanced inhibition.
This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein.
The function of this protein has been found, in Drosophila to inhibit branching of the trachea by antagonizing the BNL-FGF pathway. Also in "Drosophila" it is an antagonist of EGFR-mediated signaling in the eye. Most notably, in humans, it suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Sprouty inhibits of the Ras/mitogen-activated protein kinase (MAPK) cascade, a pathway crucial for developmental processes initiated by activation of various receptor tyrosine kinases. These proteins share a conserved, C-terminal cysteine-rich region, the SPR domain. This domain has been defined as a novel cytosol to membrane translocation domain. It has been found to be a PtdIns(4,5)P2-binding domain that targets the proteins to a cellular localization that maximizes their inhibitory potential. It also mediates homodimer formation of these proteins.