Synonyms for unfoldases or Related words with unfoldases
Examples of "unfoldases"
Today, most of Baker's work focuses on these
. She works specifically with the AAA+ unfoldase family and has done a lot of research on the ClpX unfoldase. In addition to
, she looks at adaptors, which are proteins that aid the
. The AAA+ family of
is in all organisms and plays an important role in maintaining which proteins are active within a cell.
help to destroy proteins that have become damaged or proteins that have built up too much. They are important in ensuring that proteins are properly recycled so that cells do not constantly need new amino acids. Baker wants to figure how
work and how they are controlled by cells.
Eventually, Baker left the National Institute of Health to work as an independent researcher at MIT. Here she discovered that "mu" transposons behave similarly to transposons and retrotransposons involved with bacterial resistance. Retrotransposons are transposons that first transcribe the moving gene sequence into RNA. This RNA then gets retro transcribed back into DNA, and it is this DNA that ends up being reincorporated somewhere else in the chromosome. Through her work with these different transposons, Baker started to look at
, which are a type of protein chaperone.
serve to unfold or degrade proteins found in cells.
are related to transposons because some of them release proteins that aid in transposition. When the proteins are released, transposition of the DNA sequence is stopped, and Baker wanted to know what caused the proteins to release from DNA.
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